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Accuracy of tuberculosis diagnostic tests in small ruminants: A systematic review and meta-analysis

Investigation article published in Preventive Veterinary Medicine

September 1st, 2020

Tuberculosis (TB) in small ruminants is a neglected disease despite its major impact on goat and sheep production and the global public health. The awareness of the role of small ruminants in the epidemiology of animal TB has increased in the last two decades, however, there is a lack of standardization of procedures and robust quantitative estimates on the accuracy of diagnostic TB tests in the scientific literature. To address this knowledge gap, all the available information regarding the use of ante-mortem diagnostic techniques in small ruminants was collected and summarized through a systematic review process. Furthermore, a random-effects meta-analysis was conducted to separately estimate the sensitivity (Se) and specificity (Sp) of cell-based tests among the retrieved studies in goats. Studies included in the meta-analysis were also evaluated using the Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews adapted for animal diagnostic tests (VETQUADAS). Median pooled Se estimates of the single intradermal tuberculin (SIT) test (ranged from 0.51 to 0.59), the comparative intradermal tuberculin (CIT) test (ranged from 0.30 to 0.50) and the interferon-gamma (IFN-γ) release assay (IGRA) (ranged from 0.66 to 0.72) were lower than that reported previously in cattle, regardless the interpretation criteria and the reporting of MAP infection or vaccination. However, the specificity was adequate for all the tests (ranged from 0.95 to 0.99), except for the SIT test in MAP vaccinated herds (ranged from 0.78 to 0.90). This study provides an overview of the accuracy of diagnostic tests for TB in goats, however, the considerable between-study heterogeneity found hampered the conclusive interpretation of the pooled Se and Sp estimates. Therefore, further studies in small ruminants are necessary to optimize the diagnostic Se, which could help to design effective control strategies, accelerate the eradication of TB in these species and harmonize test procedures




Roy A., Infantes-Lorenzo JA., de la Cruz ML., Dominguez L., Alvarez J. and Bezos J..




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Accuracy of tuberculosis diagnostic tests in small ruminants: A systematic review and meta-analysis

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Accuracy of tuberculosis diagnostic tests in small ruminants: A systematic review and meta-analysis


Participants:

CZ VaccinesCZ Vaccines.

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Instituto de Salud Carlos IIIServicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Universidad Francisco de VitoriaFacultad de Medicina. Universidad Francisco de Vitoria (UFV).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Preventive Veterinary Medicine
FACTOR YEAR Q
2.304 2019

NLMID: 8217463

PMID: 32739695

ISSN: 0167-5877



TITLE: Accuracy of tuberculosis diagnostic tests in small ruminants: A systematic review and meta-analysis


JOURNAL: Prev. Vet. Med.


NUMERACIÓN: 182:105102


AÑO: 2020


PUBLISHER: Elsevier Science Publishers


AUTHORS: Roy A., Infantes-Lorenzo JA., de la Cruz ML., Dominguez L., Alvarez J. and Bezos J..


VISAVET PARTICIPANTS


First
Álvaro Roy Cordero
4th
Lucas Domínguez Rodríguez
5th
Julio Álvarez Sánchez
Last
Javier Bezos Garrido

DOI: https://doi.org/ 10.1016/j.prevetmed.2020.105102


CITE THIS PUBLICATION:

Roy A., Infantes-Lorenzo JA., de la Cruz ML., Dominguez L., Alvarez J. and Bezos J. Accuracy of tuberculosis diagnostic tests in small ruminants: A systematic review and meta-analysis. Preventive Veterinary Medicine. 182:105102. 2020. (A). ISSN: 0167-5877. DOI: 10.1016/j.prevetmed.2020.105102


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