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Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period

BMC Veterinary Research publish this investigation article

June 29th, 2012

BACKGROUND: Eradication of bovine tuberculosis (bTB) through the application of test-and-cull programs is a declared goal of developed countries in which the disease is still endemic. Here, longitudinal data from more than 1,700 cattle herds tested during a 12 year-period in the eradication program in the region of Madrid, Spain, were analyzed to quantify the within-herd transmission coefficient (beta) depending on the herd-type (beef/dairy/bullfighting). In addition, the probability to recover the officially bTB free (OTF) status in infected herds depending on the type of herd and the diagnostic strategy implemented was assessed using Cox proportional hazard models. RESULTS: Overall, dairy herds showed higher beta (median 4.7) than beef or bullfighting herds (2.3 and 2.2 respectively). Introduction of interferon-gamma (IFN-gamma) as an ancillary test produced an apparent increase in the beta coefficient regardless of production type, likely due to an increase in diagnostic sensitivity. Time to recover OTF status was also significantly lower in dairy herds, and length of bTB episodes was significantly reduced when the IFN-gamma was implemented to manage the outbreak. CONCLUSIONS: Our results suggest that bTB spreads more rapidly in dairy herds compared to other herd types, a likely cause being management and demographic-related factors. However, outbreaks in dairy herds can be controlled more rapidly than in typically extensive herd types. Finally, IFN-gamma proved its usefulness to rapidly eradicate bTB at a herd-level




Alvarez J., Perez AM., Bezos J., Casal C., Romero B., Rodriguez-Campos S., Saez JL., Diaz R., Carpintero J., de Juan L. and Dominguez L..




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Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period

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Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period


Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Gobierno de Castilla-La ManchaInstituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

University of California-DavisUniversity of California-Davis (UCDAVIS).

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET).

Área de Ganadería. Dirección General de Medio Ambiente. Consejería de Medio Ambiente, Vivienda y Ordenación del Territorio.

Ministerio de Agricultura, Alimentación y Medio AmbienteÁrea de Ganadería. Ministerio de Agricultura, Alimentación y Medio Ambiente (MAGRAMA).







BMC Veterinary Research
FACTOR YEAR Q
1.861 2012

NLMID: 101249759

PMID: 22748007

ISSN: 1746-6148



TITLE: Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period


JOURNAL: BMC Vet. Res


NUMERACIÓN: 8(1):100


AÑO: 2012


PUBLISHER: BioMed Central


AUTHORS: Alvarez J., Perez AM., Bezos J., Casal C., Romero B., Rodriguez-Campos S., Saez JL., Diaz R., Carpintero J., de Juan L. and Dominguez L..


VISAVET PARTICIPANTS


First
Julio Álvarez Sánchez
3rd
Javier Bezos Garrido
5th
Beatriz Romero Martínez
10
Lucía de Juan Ferré
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/ 10.1186/1746-6148-8-100


CITE THIS PUBLICATION:

Alvarez J., Perez AM., Bezos J., Casal C., Romero B., Rodriguez-Campos S., Saez JL., Diaz R., Carpintero J., de Juan L. and Dominguez L. Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period. BMC Veterinary Research. 8(1):100. 2012. (A). ISSN: 1746-6148. DOI: 10.1186/1746-6148-8-100


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