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Evaluation of the immunogenicity and diagnostic interference caused by M. tuberculosis SO2 vaccination against tuberculosis in goats

Investigation article published in Research in Veterinary Science

December 1st, 2015

The immunogenicity and diagnostic interference caused by M. tuberculosis SO2, a prototype vaccine first time tested in goats was evaluated. Tuberculosis-free goats were distributed in four groups: [1], non-vaccinated; [2], subcutaneously (SC) BCG vaccinated; [3], intranasally (IN) SO2 vaccinated and [4], SC SO2 vaccinated. Intradermal tuberculin and IFN-γ tests using PPDs and alternative antigenic cocktails containing mainly ESAT-6 and CFP-10 (E/C) were applied at different times post-vaccination. Results showed a significant (p < 0.05) increase in the number of reactors detected using both PPD-based intradermal and IFN-γ tests at different times in all the vaccinated groups. No intradermal reactivity was detected in the vaccinated goats using a cocktail containing E/C, Rv3615c and Rv3020c. A higher overall reactivity was observed in the group [4] in comparison with the other vaccinated groups. Results showed that antigens used to differentiate BCG vaccinated animals could be potentially used to differentiate SO2 vaccinated ones




Bezos J., Casal C., Puentes E., Diez-Guerrier A., Romero B., Aguilo N., de Juan L., Martin C. and Dominguez L..




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Evaluation of the immunogenicity and diagnostic interference caused by M. tuberculosis SO2 vaccination against tuberculosis in goats

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Evaluation of the immunogenicity and diagnostic interference caused by M. tuberculosis SO2 vaccination against tuberculosis in goats



Participants:

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

BIOFABRI, S.L.BIOFABRI, S.L..

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de ZaragozaDepartamento de Microbiología, Medicina Preventiva y Salud Pública. Facultad de Medicina. Universidad de Zaragoza (UNIZAR).







Research in Veterinary Science
FACTOR YEAR Q
1.504 2015

NLMID: 401300

PMID: 26679799

ISSN: 0034-5288



TITLE: Evaluation of the immunogenicity and diagnostic interference caused by M. tuberculosis SO2 vaccination against tuberculosis in goats


JOURNAL: Res. Vet. Sci.


NUMERACIÓN: 103(2015):73-79


AÑO: 2015


PUBLISHER: Elsevier


AUTHORS: Bezos J., Casal C., Puentes E., Diez-Guerrier A., Romero B., Aguilo N., de Juan L., Martin C. and Dominguez L..


VISAVET PARTICIPANTS


First
Javier Bezos Garrido
4th
Alberto Antoine Díez Guerrier
5th
Beatriz Romero Martínez
7th
Lucía de Juan Ferré
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1016/j.rvsc.2015.09.017


CITE THIS PUBLICATION:

Bezos J., Casal C., Puentes E., Diez-Guerrier A., Romero B., Aguilo N., de Juan L., Martin C. and Dominguez L. Evaluation of the immunogenicity and diagnostic interference caused by M. tuberculosis SO2 vaccination against tuberculosis in goats. Research in Veterinary Science. 103(2015):73-79. 2015. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2015.09.017


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