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Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain

Investigation article published in BioMed Research International (Journal of Biomedicine and Biotechnology)

March 3rd, 2014

Leishmaniasis is one of most important neglected zoonosis and remains endemic in at least 88 developing countries in the world. In addition, anthropogenic environmental changes in urban areas are leading to its emergency world-wide. Zoonotic leishmaniasis control might only be achieved by an integrated approach targeting both the human host and the animal reservoirs, which in certain sylvatic cycles are yet to be identified. Recently, hares have been pointed out as competent reservoirs of Leishmania infantum in Spain, but the role of other lagomorphs has not been clarified. Here, 69 rabbits (Oryctolagus cuniculus) from a natural area in Madrid in which a high density was present were analyzed using indirect (immunofluorescence antibody test, IFAT) and direct (PCR, culture) techniques. Fifty-seven (82.6%) of the animals were positive to at least one technique, with IFAT yielding the highest proportion of positive samples. L. infantum was isolated in 13% animals demonstrating the occurrence of infection in this setting. Our results suggest that rabbits could play a role of competent reservoir of L. infantum and demonstrate that the prevalence of infection is high in the analyzed area




Garcia N., Moreno I., Alvarez J., de la Cruz ML., Navarro A., Perez-Sancho M., Garcia-Seco T., Rodriguez-Bertos A., Conty ML., Torano A., Prieto A., Dominguez L. and Dominguez M.




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Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain

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Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain


Participants:

Universidad ComplutenseServicio de Zoonosis Emergentes, de Baja Prevalencia y Agresivos Biológicos (NED). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Instituto de Salud Carlos IIIServicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Ayuntamiento de MadridMadrid Salud. Ayuntamiento de Madrid.

Comunidad de MadridInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid.







FACTOR YEAR Q
1.579 2014

NLMID: 101600173

PMID: 24724079

ISSN: 2314-6133



TITLE: Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain


JOURNAL: Biomed Res Int


NUMERACIÓN: 2014: Article ID 318254, 5 pages


AÑO: 2014


PUBLISHER: Hindawi Pub. Co


AUTHORS: Garcia N., Moreno I., Alvarez J., de la Cruz ML., Navarro A., Perez-Sancho M., Garcia-Seco T., Rodriguez-Bertos A., Conty ML., Torano A., Prieto A., Dominguez L. and Dominguez M.


VISAVET PARTICIPANTS


First
Nerea García Benzaquén
3rd
Julio Álvarez Sánchez
5th
Alejandro Navarro Gómez
6th
Marta Pérez Sancho
7th
Teresa García-Seco Romero
8th
Antonio Manuel Rodríguez Bertos
12th
Lucas Domínguez Rodríguez

DOI: https://doi.org/ 10.1155/2014/318254


CITE THIS PUBLICATION:

Garcia N., Moreno I., Alvarez J., de la Cruz ML., Navarro A., Perez-Sancho M., Garcia-Seco T., Rodriguez-Bertos A., Conty ML., Torano A., Prieto A., Dominguez L. and Dominguez M. Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain. BioMed Research International (Journal of Biomedicine and Biotechnology). 2014: Article ID 318254, 5 pages. 2014. (A). ISSN: 2314-6133. DOI: 10.1155/2014/318254


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