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Molecular epidemiology underlines the importance of Mycobacterium caprae in livestock and wildlife

Oral communication in 31st Annual Congress of the European Society of Mycobacteriology (ESM 2010)

July 4th, 2010

Rodriguez-Campos S., Bezos J., de Juan L., Romero B., Alvarez J., Castellanos E., Gonzalez S., Saez-LLorente JL., Mateos A., Dominguez L. and Aranaz A.

Mycobacterium caprae (M. caprae) is a member of the M. tuberculosis complex which was first described as the main etiological agent of caprine tuberculosis in Spain. However, this pathogen can also infect other animal species and human beings.
In the present study we have characterised M. caprae isolates from 791 animals by DVR-spoligotyping. The diversity of spoligotypes based on the number of patterns (n=15) and discrimination index (D=0.58) is lower compared to M. bovis. Additionally, we used Variable Number Tandem Repeat (VNTR) typing when more than one spoligotype was observed in the same herd. M. caprae infection was widespread in Spain and although the majority of the strains (n=536) were identified in goats, we also observed M. caprae in other domestic and wild animal species [cows (n=235), sheep (n=2), pigs (n=2), wild boars (n=14), red deer (n=1), and fox (n=1)]. Proportion of M. caprae isolates from bovine samples and M. caprae-infected cattle herds increased consistently in the period 2004-2009, highlighting an emergence of this pathogen in cattle.
Unlike results found in reports from other European countries, we observed that the epidemiology in Spain is driven by caprine infections. Considering the damage that M. caprae causes in caprine flocks, the possibility of its transmission to other animal species, and its zoonotic potential, we suggest that relevant legislation should be adapted to address the infection as it is done with M. bovis.




Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).


Link to 31st Annual Congress of the European Society of Mycobacteriology (ESM 2010)





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31st Annual Congress of the European Society of Mycobacteriology (ESM 2010)


31st Annual Congress of the European Society of Mycobacteriology (ESM 2010)
July 4th-7th, 2010
Bled
Slovenia

TITLE: Molecular epidemiology underlines the importance of Mycobacterium caprae in livestock and wildlife


TYPE: Oral communication


AUTHORS: Rodriguez-Campos S., Bezos J., de Juan L., Romero B., Alvarez J., Castellanos E., Gonzalez S., Saez-LLorente JL., Mateos A., Dominguez L. and Aranaz A.


VISAVET PARTICIPANTS


2nd
Javier Bezos Garrido
3rd
Lucía de Juan Ferré
4th
Beatriz Romero Martínez
5th
Julio Álvarez Sánchez
7th
Sergio González Domínguez
10
Lucas Domínguez Rodríguez

DATE: July 4th, 2010


CITE THIS COMMUNICATION:

Rodriguez-Campos S., Bezos J., de Juan L., Romero B., Alvarez J., Castellanos E., Gonzalez S., Saez-LLorente JL., Mateos A., Dominguez L. and Aranaz A. Molecular epidemiology underlines the importance of Mycobacterium caprae in livestock and wildlife. 31st Annual Congress of the European Society of Mycobacteriology (ESM 2010), European Society of Mycobacteriology, Bled, Slovenia, July 4th, 2010. (Oral communication)


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