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Spatial dynamics of bovine tuberculosis in the autonomous community of madrid, Spain (2010-2012)

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December 23rd, 2014

Progress in control of bovine tuberculosis (bTB) is often not uniform, usually due to the effect of one or more sometimes unknown epidemiological factors impairing the success of eradication programs. Use of spatial analysis can help to identify clusters of persistence of disease, leading to the identification of these factors thus allowing the implementation of targeted control measures, and may provide some insights of disease transmission, particularly when combined with molecular typing techniques. Here, the spatial dynamics of bTB in a high prevalence region of Spain were assessed during a three year period (2010-2012) using data from the eradication campaigns to detect clusters of positive bTB herds and of those infected with certain Mycobacterium bovis strains (characterized using spoligotyping and VNTR typing). In addition, the within-herd transmission coefficient (β) was estimated in infected herds and its spatial distribution and association with other potential outbreak and herd variables was evaluated. Significant clustering of positive herds was identified in the three years of the study in the same location ("high risk area"). Three spoligotypes (SB0339, SB0121 and SB1142) accounted for >70% of the outbreaks detected in the three years. VNTR subtyping revealed the presence of few but highly prevalent strains within the high risk area, suggesting maintained transmission in the area. The spatial autocorrelation found in the distribution of the estimated within-herd transmission coefficients in herds located within distances <14 km and the results of the spatial regression analysis, support the hypothesis of shared local factors affecting disease transmission in farms located at a close proximity




de la Cruz ML., Perez A., Bezos J., Pages E., Casal C., Carpintero J., Romero B., Dominguez L., Diaz R., Alvarez J. and Barker CM.




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Spatial dynamics of bovine tuberculosis in the autonomous community of madrid, Spain (2010-2012)

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Spatial dynamics of bovine tuberculosis in the autonomous community of madrid, Spain (2010-2012)


Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of MinnesotaVeterinary Pathobiology Department. University of Minnesota (UMM).

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Área de Ganadería. Dirección General de Medio Ambiente. Consejería de Medio Ambiente, Vivienda y Ordenación del Territorio.

University of California-DavisDepartment of Pathology, Microbiology and Immunology. School of Veterinary Medicine. University of California-Davis (UCDAVIS).







PLoS ONE
FACTOR YEAR Q
3.234 2014

NLMID: 101285081

PMID: 25536514

ISSN: 1932-6203



TITLE: Spatial dynamics of bovine tuberculosis in the autonomous community of madrid, Spain (2010-2012)


JOURNAL: PLoS ONE


NUMERACIÓN: 9(12):e115632


AÑO: 2014


PUBLISHER: Public Library Science


AUTHORS: de la Cruz ML., Perez A., Bezos J., Pages E., Casal C., Carpintero J., Romero B., Dominguez L., Diaz R., Alvarez J. and Barker CM.


VISAVET PARTICIPANTS


3rd
Javier Bezos Garrido
7th
Beatriz Romero Martínez
8th
Lucas Domínguez Rodríguez
10
Julio Álvarez Sánchez

DOI: https://doi.org/ 10.1371/journal.pone.0115632


CITE THIS PUBLICATION:

de la Cruz ML., Perez A., Bezos J., Pages E., Casal C., Carpintero J., Romero B., Dominguez L., Diaz R., Alvarez J. and Barker CM. Spatial dynamics of bovine tuberculosis in the autonomous community of madrid, Spain (2010-2012). PLoS ONE. 9(12):e115632. 2014. (A). ISSN: 1932-6203. DOI: 10.1371/journal.pone.0115632


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