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Spleen and head kidney differential gene expression patterns in trout infected with Lactococcus garvieae correlate with spleen granulomas

Investigation published in Veterinary Research

May 2nd, 2019

Lactococcus garvieae is a significant pathogen in aquaculture with a potential zoonotic risk. To begin to characterize the late immune response of trout to lactococcosis, we selected infected individuals showing clinical signs of lactococcosis. At the time lactococcosis clinical signs appeared, infection by L. garvieae induced a robust inflammatory response in the spleen of rainbow trout, which correlated with abundant granulomatous lesions. The response in kidney goes in parallel with that of spleen, and most of the gene regulations are similar in both organs. A correlation existed between the early inflammatory granulomas in spleen (containing macrophages with internalized L. garvieae) and up-regulated gene sets, which defined the presence of macrophages and neutrophils. This is the first analysis of the immune transcriptome of rainbow trout following L. garvieae infection during the initiation of adaptive immune mechanisms and shows a transcriptome induction of antibody response by both IgM (+) and IgT (+) spleen B cells to respond to systemic infection. These results increase our understanding of lactococcosis and pave the way for future research to improve control measures of lactococcosis on fish farms




Castro R., Coll J., Blanco MDM., Rodriguez-Bertos A., Jouneau L., Fernandez-Garayzabal JF. and Gibello A.




See this article
Spleen and head kidney differential gene expression patterns in trout infected with Lactococcus garvieae correlate with spleen granulomas

See it on NLM PubMed
Spleen and head kidney differential gene expression patterns in trout infected with Lactococcus garvieae correlate with spleen granulomas

Participants:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Institut National de la Recherche AgronomiqueInstitut National de la Recherche Agronomique (INRA).

Virologie et Immunologie Moléculaires. Université Paris-Saclay.

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaDepartamento de Biotecnología. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Servicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







FACTOR YEAR Q
2.903 2017

NLMID: 9309551

PMID: 31046823

ISSN: 0928-4249



TITLE: Spleen and head kidney differential gene expression patterns in trout infected with Lactococcus garvieae correlate with spleen granulomas


JOURNAL: Vet. Res.


NUMERACIÓN: 50(1):32


AÑO: 2019


PUBLISHER: EDP Sciences


AUTHORS: Castro R., Coll J., Blanco MDM., Rodriguez-Bertos A., Jouneau L., Fernandez-Garayzabal JF. and Gibello A.


VISAVET PARTICIPANTS


4th
Antonio Manuel Rodríguez Bertos
6th
José Francisco Fernández-Garayzabal Fernández

DOI: https://doi.org/ 10.1186/s13567-019-0649-8


CITE THIS PUBLICATION:

Castro R., Coll J., Blanco MDM., Rodriguez-Bertos A., Jouneau L., Fernandez-Garayzabal JF. and Gibello A. Spleen and head kidney differential gene expression patterns in trout infected with Lactococcus garvieae correlate with spleen granulomas. Veterinary Research. 50(1):32. 2019. (A). ISSN: 0928-4249. DOI: 10.1186/s13567-019-0649-8


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