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Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain

Investigation article published in Journal of Clinical Microbiology

November 1st, 2004

Spoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases




Aranaz A., Romero B., Montero N., Alvarez J., Bezos J., de Juan L., Mateos A. and Dominguez L..




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Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain

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Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain


Participants:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Journal of Clinical Microbiology
FACTOR YEAR Q
3.439 2004

NLMID: 7505564

PMID: 15528751

ISSN: 0095-1137



TITLE: Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain


JOURNAL: J. Clin. Microbiol.


NUMERACIÓN: 42(11):5388-91


AÑO: 2004


PUBLISHER: American Society for Microbiology


AUTHORS: Aranaz A., Romero B., Montero N., Alvarez J., Bezos J., de Juan L., Mateos A. and Dominguez L..


VISAVET PARTICIPANTS


2nd
Beatriz Romero Martínez
4th
Julio Álvarez Sánchez
5th
Javier Bezos Garrido
6th
Lucía de Juan Ferré
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/ 10.1128/JCM.42.11.5388-5391.2004


CITE THIS PUBLICATION:

Aranaz A., Romero B., Montero N., Alvarez J., Bezos J., de Juan L., Mateos A. and Dominguez L. Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain. Journal of Clinical Microbiology. 42(11):5388-91. 2004. (A). ISSN: 0095-1137. DOI: 10.1128/JCM.42.11.5388-5391.2004


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