Contact
Mycobacteria Unit
VISAVET Health Surveillance Centre
Universidad Complutense
Av. Puerta de Hierro s/n. 28040 Madrid. Spain
e-mail:
Head office phone: (+34) 913 943 992
Laboratory phone: (+34) 913 944 002
Fax: (+34) 913 943 795
MYC Unit routinely performs bacteriological and molecular diagnose of infections produced mainly by members of the Mycobacterium tuberculosis and avium complexes. Moreover, it realizes studies of molecular and epidemiological characterization. The main lines of research are to set up new technologies for the diagnosis (in vivo e in vitro) of the main principal diseases caused by mycobacteria, as well as the development of new technology for molecular characterization studies. The laboratory also designs field studies of control and eradication programs in problem situations for subsequent implementation at a national level. The laboratory also advises Animal Health Services of the Autonomous Communities, farmers and veterinarians, as well as Ministries. In addition as European Union Reference Laboratory for Bovine Tuberculosis, they provide technical and scientific support to all National Reference Laboratories (NRL) and the official veterinary services of the European Union.
Research
Research lines:
Next scientific publications:
- Ortega Martín J., Infantes-Lorenzo JA., Bezos J., Roy A., de Juan L., Romero B., Moreno I., Gómez-Buendía A., Agullo-Ros I., Dominguez L. and Dominguez M.. Evaluation of the P22 ELISA for the detection of Mycobacterium bovis-specific antibodies in oral fluid samples obtained from goats. Frontiers in veterinary science. In Press (A)
Last scientific publications:
- Blanco-Vazquez C., Doria-Barral T., Romero B., Queipo M., Merediz I., Quiros P., Armenteros JA., Juste R., Dominguez L., Dominguez M., Casais R. and Balseiro A.. Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain. Animals, 11(5):1294. 2021. (A)
- Gómez-Buendía A., Romero B., Bezos J., Lozano F., de Juan L. and Alvarez J.. Spoligotype-specific risk of finding lesions in tissues from cattle infected by Mycobacterium bovis. BMC Veterinary Research, 17(1):148. 2021. (A)
- Pozo P., Cespedes-Cardenas N., Bezos J., Romero B., Grau A., Nacar J., Saez JL., Minguez O. and Alvarez J.. Evaluation of the performance of slaughterhouse surveillance for bovine tuberculosis detection in Castilla y Leon, Spain. Preventive Veterinary Medicine, 189:105307. 2021. (A)
- Perez del Val B., Romero B., Tortola MT., Herrera-Leon L., Pozo P., Mercader I., Saez JL., Domingo M. and Vidal E.. Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017-2018. Emerging Infectious Diseases, 27(4):1241-1243. 2021. (L)
- Lorente-Leal V., Liandris E., Pacciarini M., Botelho A., Kenny K., Loyo B., Fernandez R., Bezos J., Dominguez L., de Juan L. and Romero B.. Direct PCR on tissue samples to detect Mycobacterium tuberculosis complex: an alternative to the bacteriological culture. Journal of Clinical Microbiology, 01404-20. 2020. (A)
Last PhD thesis:
- Pilar Pozo Piñol. Use of Epidemiological Analytic Tools and Molecular Characterization Techniques to Inform Bovine Tuberculosis Eradication Programs. 2020.
- Álvaro Roy Cordero. Evaluation of new vaccines against tuberculosis in goats and advances in their immunological diagnosis. 2020.
- Jose Antonio Infantes Lorenzo. Immunoproteomic characterization of protein derivatives from Mycobacterium bovis, Mycobacterium avium (subspecies avium and paratuberculosis) and Corynebacterium pseudotuberculosis. Application in diagnosis. 2018.
- Carmen Casal Comendador. Diagnosis of tuberculosis in ruminants and camelids: optimization of cell-based and humoral tests. 2016. (Premio Laboratorios Ovejero, Europea)
- Yurena Navarro García. Detección, caracterización y análisis funcional de la complejidad clonal en la tuberculosis humana y bovina. 2015.
Outreach
Last outreach publications:
- Gonzalez S., Lozano F., Alvarez J., Romero B., Bezos J. and de Juan L.. Tuberculosis in the new Animal Health Law. VISAVET Outreach Journal, VISAVET Health Surveillance Centre (U.C.M.). 2021.
- Saez JL., Juste R., Munoz MJ., Minguez O. and Dominguez L.. Introducción: la tuberculosis y sus antecedentes históricos, dónde estamos y cómo hemos llegado a la situación actual. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 1:16-28, Ministerio de Agricultura, Pesca y Alimentación. 2020.
- Benitez-Medina JL., Martinez R. and Dominguez L.. Tuberculosis como zoonosis. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 3:42-52, Ministerio de Agricultura, Pesca y Alimentación. 2020.
- Lorente-Leal V., Pozo P., Alvarez J., Romero B. and de Juan L.. Avances en investigación. Epidemiología. Caracterización molecular y secuenciación masiva. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 4.1.1:54-57, Ministerio de Agricultura, Pesca y Alimentación. 2020.
- Pozo P., Alvarez J., Allepuz A. and Ciaravino G.. Avances en investigación. Epidemiología. Modelos de transmisión. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 4.1.2:67-77, Ministerio de Agricultura, Pesca y Alimentación. 2020.
Last communications:
- de Juan L.. Control de tuberculosis en España: historia, situación actual y diagnóstico. Tuberculosis Animal: epidemiología y control. 2021. (Online communication)
- Lorente-Leal V., Farrell D., Alvarez J., Romero B., Gordon S. y de Juan L.. Whole genome sequencing: evaluation of variant calling pipelines for the study of animal tuberculosis. One Health EJP Annual Scientific Meeting. 2021. (Poster communication)
- Ortega Martín J., Roy A., Romero B., de Juan L., Moreno I., Infantes-Lorenzo JA., Gómez-Buendía A., Lorente-Leal V., Dominguez M., Dominguez L. y Bezos J.. Milk samples for immunological diagnosis of caprine tuberculosis. One Health EJP Annual Scientific Meeting. 2021. (Poster communication)
- Ortega Martín J., Infantes-Lorenzo JA., Roy A., de Juan L., Romero B., Moreno I., Gómez-Buendía A., Agullo-Ros I., Lorente-Leal V., Dominguez L., Dominguez M., Bezos J. y Pozo P.. Antibody-based diagnosis of caprine tuberculosis using oral fluid samples. One Health EJP Annual Scientific Meeting. 2021. (Poster communication)
- Pozo P., Cespedes-Cardenas N., Bezos J., Romero B., Grau A., Nacar J., Saez JL., Minguez O. y Alvarez J.. Evaluation of the performance of slaughterhouse surveillance for bovine tuberculosis detection in Castilla y León, Spain. One Health EJP Annual Scientific Meeting. 2021. (Poster communication)
