Contact
Mycobacteria Unit
VISAVET Health Surveillance Centre
Universidad Complutense
Av. Puerta de Hierro s/n. 28040 Madrid. Spain
e-mail:
Head office phone: (+34) 913 943 992
Laboratory phone: (+34) 913 944 002
Fax: (+34) 913 943 795
MYC Unit routinely performs bacteriological and molecular diagnose of infections produced mainly by members of the Mycobacterium tuberculosis and avium complexes. Moreover, it realizes studies of molecular and epidemiological characterization. The main lines of research are to set up new technologies for the diagnosis (in vivo e in vitro) of the main principal diseases caused by mycobacteria, as well as the development of new technology for molecular characterization studies. The laboratory also designs field studies of control and eradication programs in problem situations for subsequent implementation at a national level. The laboratory also advises Animal Health Services of the Autonomous Communities, farmers and veterinarians, as well as Ministries. In addition as European Union Reference Laboratory for Bovine Tuberculosis, they provide technical and scientific support to all National Reference Laboratories (NRL) and the official veterinary services of the European Union.
Research
Research lines:
Last scientific publications:
- Pozo P., Lorente-Leal V., Robbe-Austerman S., Hicks J., Stuber T., Bezos J., de Juan L., Saez-Llorente JL., Romero B., Alvarez J. and on behalf of the Spanish Network on Surveillance Monitoring of Animal Tuberculosis.. Use of Whole-Genome Sequencing to Unravel the Genetic Diversity of a Prevalent Mycobacterium bovis Spoligotype in a Multi-Host Scenario in Spain. Frontiers in Microbiology, 13:915843. 2022. (A)
- Ruiz-Cabello J., Sevilla AI., Olaizola E., Bezos J., Miguel-Coello AB., Munoz-Mendoza M., Beraza M., Garrido JM. and Izquierdo-Garcia JL.. Benchtop nuclear magnetic resonance-based metabolomic approach for the diagnosis of bovine tuberculosis. Transboundary and Emerging Diseases, 69(4):e859-e870. 2022. (A)
- Ortega J., Infantes-Lorenzo JA., Roy A., de Juan L., Romero B., Moreno I., Dominguez M., Dominguez L. and Bezos J.. Factors affecting the performance of P22 ELISA for the diagnosis of caprine tuberculosis in milk samples. Research in Veterinary Science, 145:40-45. 2022. (A)
- Juste RA., Ferreras-Colino E., de la Fuente JM., Dominguez M., Risalde MA., Dominguez L., Cabezas-Cruz A. and Gortazar C.. Heat inactivated mycobacteria, alpha-gal and zebra fish: insights gained from experiences with two promising trained immunity inductors and a validated animal model. Immunology, 2022. (A)
- Sridhara AA., Johnathan-Lee A., Elahi R., Sikar-Gang A., Lambotte P., Esfandiari J., de Juan L., Gortazar C., Marpe BN., Thacker TC., Palmer MV., Waters WR. and Lyashchenko K.. Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms. Veterinary Immunology and Immunopathology, 248:110419. 2022. (A)
Last PhD thesis:
- Pilar Pozo Piñol. Use of Epidemiological Analytic Tools and Molecular Characterization Techniques to Inform Bovine Tuberculosis Eradication Programs. 2020. (Doctorado Europeo)
- Álvaro Roy Cordero. Evaluation of new vaccines against tuberculosis in goats and advances in their immunological diagnosis. 2020.
- Jose Antonio Infantes Lorenzo. Immunoproteomic characterization of protein derivatives from Mycobacterium bovis, Mycobacterium avium (subspecies avium and paratuberculosis) and Corynebacterium pseudotuberculosis. Application in diagnosis. 2018. (Doctorado Europeo)
- Carmen Casal Comendador. Diagnosis of tuberculosis in ruminants and camelids: optimization of cell-based and humoral tests. 2016. (Premio Laboratorios Ovejero, Doctorado Europeo)
- Yurena Navarro García. Detección, caracterización y análisis funcional de la complejidad clonal en la tuberculosis humana y bovina. 2015.
Outreach
Last outreach publications:
- Gonzalez S., Lozano F., Alvarez J., Romero B., Bezos J. and de Juan L.. Tuberculosis in the new Animal Health Law. VISAVET Outreach Journal, VISAVET Health Surveillance Centre (U.C.M.). 2021.
- Roy A., Dominguez L., Puentes E. and Bezos J.. Evaluación de nuevas vacunas frente a la tuberculosis caprina. Tierras. Caprino, 33:20-25, Sociedad Española de Ovinotecnia y Caprinotecnia. 2021.
- Saez JL., Juste R., Munoz MJ., Minguez O. and Dominguez L.. Introducción: la tuberculosis y sus antecedentes históricos, dónde estamos y cómo hemos llegado a la situación actual. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 1:16-28, Ministerio de Agricultura, Pesca y Alimentación. 2020.
- Benitez-Medina JL., Martinez R. and Dominguez L.. Tuberculosis como zoonosis. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 3:42-52, Ministerio de Agricultura, Pesca y Alimentación. 2020.
- Lorente-Leal V., Pozo P., Alvarez J., Romero B. and de Juan L.. Avances en investigación. Epidemiología. Caracterización molecular y secuenciación masiva. Tuberculosis animal: una aproximación desde la perspectiva de la Ciencia y la Administración. Ed. 1. 4.1.1:54-57, Ministerio de Agricultura, Pesca y Alimentación. 2020.
Last communications:
- Alvarez J.. Resistencia antimicrobiana en patógenos animales: ¿Cuánto sabemos y cuánto nos queda por saber?. Webseminar de la Organizacion Colegial Veterinaria. 2022. (Oral communication)
- Ortega J., Roy A., Romero B., de Juan L., Grau A., Nacar J., Minguez O., Alvarez J. y Bezos J.. Análisis longitudinal del programa de erradicación de tuberculosis caprina en Castilla y León: cerca del objetivo. I Congreso Internacional de Sanidad y Bienestar Animal. 2022. (Poster communication)
- Ortega J., Romero B., de Juan L., Moreno I., Dominguez L., Dominguez M., Infantes-Lorenzo JA. y Bezos J.. Detección de anticuerpos frente al complejo M. tuberculosis empleando el ELISA-P22 en muestras de heces caprinas. I Congreso Internacional de Sanidad y Bienestar Animal. 2022. (Poster communication)
- Alvarez J., Bicout D., Damborg P., Dewulf J., Drewe J., Guardabassi L., Hilbert F., Mader R., Bano L., Cid D., Davies P., Diez-Guerrier A., Diez de Tejada P., Guatteo R., Pardon B., Oswaldi V. y Baldinelli F.. Identification of the most relevant AMR bacteria causing disease in livestock and companion animals in the EU. 16th International Symposium of Veterinary Epidemiology and Economics (ISVEE 16). 2022. (Poster communication)
- Gómez-Buendía A., Pozo P., Picasso C., Branscum A., Perez A. y Alvarez J.. Accuracy of Tests for Diagnosis of Animal Tuberculosis: Moving Away from the Golden Calf (and towards Bayesian Models). 16th International Symposium of Veterinary Epidemiology and Economics (ISVEE 16). 2022. (Oral communication)
