Contact
Mycobacteria Unit
VISAVET Health Surveillance Centre
Universidad Complutense
Av. Puerta de Hierro s/n. 28040 Madrid. Spain
e-mail:
Head office phone: (+34) 913 943 992
Laboratory phone: (+34) 913 944 002
Fax: (+34) 913 943 795
MYC Unit routinely performs bacteriological and molecular diagnose of infections produced mainly by members of the Mycobacterium tuberculosis and avium complexes. Moreover, it realizes studies of molecular and epidemiological characterization. The main lines of research are to set up new technologies for the diagnosis (in vivo e in vitro) of the main principal diseases caused by mycobacteria, as well as the development of new technology for molecular characterization studies. The laboratory also designs field studies of control and eradication programs in problem situations for subsequent implementation at a national level. The laboratory also advises Animal Health Services of the Autonomous Communities, farmers and veterinarians, as well as Ministries. In addition as European Union Reference Laboratory for Bovine Tuberculosis, they provide technical and scientific support to all National Reference Laboratories (NRL) and the official veterinary services of the European Union.
Research
Research lines:
Last scientific publications:
- Roy A., Tome-Sanchez I., Romero B., Lorente-Leal V., Infantes-Lorenzo JA., Dominguez M., Martin C., Aguilo N., Puentes E., Rodriguez E., de Juan L., Risalde MA., Gortazar C., Dominguez L. and Bezos J.. Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis. Veterinary Research, 50:82. 2019. (A)
- Diez-Delgado I., Sevilla IA., Garrido JM., Romero B., Geijo MV., Dominguez L., Juste RA., Aranaz A., de la Fuente J. and Gortazar C.. Tuberculosis vaccination sequence effect on protection in wild boar. Comparative Immunology, Microbiology and Infectious Diseases, 66:101329. 2019. (A)
- Monedero M., Infantes-Lorenzo JA., Moreno I., Martin AB., Macias RIR., Torano A. and Dominguez M.. Development and characterization of mouse monoclonal antibodies to eight human complement components: analysis of reactivity with orthologs of nine mammalian genera. Comparative Immunology, Microbiology and Infectious Diseases, 62:7-12. 2019. (A)
- Lorente-Leal V., Liandris E., Castellanos E., Bezos J., Dominguez L., de Juan L. and Romero B.. Validation of a Real-Time PCR for the Detection of Mycobacterium tuberculosis Complex Members in Bovine Tissue Samples. Frontiers in veterinary science, 6(61):1-9. 2019. (A)
- Infantes-Lorenzo JA., Moreno I., Roy A., Risalde MA., Balseiro A., de Juan L., Romero B., Bezos J., Puentes E., Akerstedt J., Tessema T., Gortazar C., Dominguez L. and Dominguez M.. Specificity of serological test for detection of tuberculosis in cattle, goats, sheep and pigs under different epidemiological situations. BMC Veterinary Research, 15(1):70. 2019. (A)
Last PhD thesis:
- Jose Antonio Infantes Lorenzo. Immunoproteomic characterization of protein derivatives from Mycobacterium bovis, Mycobacterium avium (subspecies avium and paratuberculosis) and Corynebacterium pseudotuberculosis. Application in diagnosis. 2018.
- Carmen Casal Comendador. Diagnosis of tuberculosis in ruminants and camelids: optimization of cell-based and humoral tests. 2016. (Premio Laboratorios Ovejero, Europea)
- Yurena Navarro García. Detección, caracterización y análisis funcional de la complejidad clonal en la tuberculosis humana y bovina. 2015.
- Sabrina Rodríguez Campos. Molecular epidemiology of Mycobacterium bovis and Mycobacterium caprae in Spain. 2012. (Premio Extraordinario de Doctorado curso 2011-2012, Mención Europea)
- Javier Bezos Garrido. Tuberculosis in goats: study of immune response and contributions to diagnosis. 2011.
Outreach
Last outreach publications:
- Bezos J., Romero B., de Juan L., Gonzalez S. and Saez JL.. Procedural manual for intradermotuberculinization and gamma-interferon tests performing. 2019-2020. Ministerio de Agricultura, Pesca y Alimentación (MAPA) y Centro de Vigilancia Sanitaria Veterinaria (VISAVET). UCM.. 2019.
- Romero B. and Bezos J.. Ofensiva contra la tuberculosis en caprino. Tierras. Caprino, 24:60-65, OVIespaña. 2018.
- Briones V., Bezos J. and Alvarez J.. Medicina Preventiva Veterinaria: concepto y actualización. Profesión Veterinaria, 91(2018/19):20-23, Colegio Oficial de Veterinarios de Madrid. 2018.
- Roy A., Gonzalez S., Romero B., de Juan L., Dominguez L. and Bezos J.. Método de segregación como medida de control y erradicación de la tuberculosis caprina (y II). Albéitar, 215:26-28, Asís. 2018.
- Roy A., Gonzalez S., Romero B., de Juan L., Dominguez L. and Bezos J.. Método de segregación como medida de control y erradicación de la tuberculosis caprina. Albéitar, 214:20-22, Servet-Grupo Asís Biomedia S.L... 2018.
Last communications:
- Pozo P., Minguez O., Grau A., Bezos J., Nacar J., Romero B., de Juan L. y Alvarez J.. To be or not to be (confirmed through bacteriology): spatial epidemiology of bovine tuberculosis in a low prevalence region in Spain. GeoVet 2019. Novel spatio-temporal approaches in the era of Big Data. 2019. (Oral communication)
- Teng KT., Martinez-Aviles M., Ugarte-Ruiz M., Barcena C., de la Torre A., Lopez G. y Alvarez J.. O, Salmonella, Where Art Thou? Modelling Salmonella infection in swine farms in Spain using Hamiltonian Monte Carlo methods. GeoVet 2019. Novel spatio-temporal approaches in the era of Big Data. 2019. (Oral communication)
- Lorente-Leal V.. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. VISAVET Journal Club. 2019. (Oral communication)
- Bezos J.. En tuberculosis no se puede achacar todo a las técnicas diagnósticas. Profesionales. 2019. (Press interview)
- Pozo P.. Epidemiología de la tuberculosis bovina en España. Programa de erradicación, técnicas de diagnóstico, actividades VISAVET-EU-RL y estudios epidemiológicos. Oportunidades para investigación y desarrollo en epidemiología de Tuberculosis bovina. 2019. (Oral communication)
