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Clinical Course and Gross Pathological Findings in Wild Boar Infected with a Highly Virulent Strain of African Swine Fever Virus Genotype II

Investigación publicada en Pathogens

22 de septiembre de 2020

African swine fever (ASF) is a notifiable disease that in recent years has spread remarkably in Europe and Asia. Eurasian wild boar (Sus scrofa) plays a key role in the maintenance and spread of the pathogen. Here we examined gross pathology of infection in wild boar with a highly virulent, hemadsorbing genotype II ASF virus (ASFV) strain. To this end, six wild boars were intramuscularly inoculated with the 10 HAD50 Arm07 ASFV strain, and 11 wild boars were allowed to come into direct contact with the inoculated animals. No animals survived the infection. Clinical course, gross pathological findings and viral genome quantification by PCR in tissues did not differ between intramuscularly inoculated or contact-infected animals. Postmortem analysis showed enlargement of liver and spleen; serosanguinous effusion in body cavities; and multiple hemorrhages in lungs, endocardium, brain, kidneys, urinary bladder, pancreas, and alimentary system. These results provide detailed insights into the gross pathology of wild boar infected with a highly virulent genotype II ASFV strain. From a didactic point of view, this detailed clinical course and macroscopic description may be essential for early postmortem detection of outbreaks in wild boar in the field and contribute to disease surveillance and prevention efforts




Rodriguez-Bertos A., Cadenas-Fernández E., Rebollada A., Porras-Gonzalez N., Mayoral-Alegre F., Barreno San Antolín L., Kosowska A., Tome-Sanchez I., Barasona JA. y Sanchez-Vizcaino JM..




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Clinical Course and Gross Pathological Findings in Wild Boar Infected with a Highly Virulent Strain of African Swine Fever Virus Genotype II

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Clinical Course and Gross Pathological Findings in Wild Boar Infected with a Highly Virulent Strain of African Swine Fever Virus Genotype II


Participantes:

Universidad ComplutenseServicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Pathogens
FACTOR YEAR Q
3.018 2019

NLMID: 101596317

PMID: 32842614

ISSN: 2076-0817



TÍTULO: Clinical Course and Gross Pathological Findings in Wild Boar Infected with a Highly Virulent Strain of African Swine Fever Virus Genotype II


REVISTA: Pathogens


NUMERACIÓN: 9(9):E688


AÑO: 2020


EDITORIAL: MDPI


AUTORES: Rodriguez-Bertos A., Cadenas-Fernández E., Rebollada A., Porras-Gonzalez N., Mayoral-Alegre F., Barreno San Antolín L., Kosowska A., Tome-Sanchez I., Barasona JA. and Sanchez-Vizcaino JM..


PARTICIPANTES VISAVET


First
Antonio Manuel Rodríguez Bertos
2nd
Estefanía Cadenas Fernández
3rd
Agustín Miguel Rebollada Merino
4th
Néstor Porras González
5th
Francisco José Mayoral Alegre
7th
Aleksandra Kosowska
9th
José Ángel Barasona García-Arévalo
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3390/pathogens9090688


CITA ESTA PUBLICACIÓN:

Rodriguez-Bertos A., Cadenas-Fernández E., Rebollada A., Porras-Gonzalez N., Mayoral-Alegre F., Barreno San Antolín L., Kosowska A., Tome-Sanchez I., Barasona JA. y Sanchez-Vizcaino JM. Clinical Course and Gross Pathological Findings in Wild Boar Infected with a Highly Virulent Strain of African Swine Fever Virus Genotype II. Pathogens. 9(9):E688. 2020. (A). ISSN: 2076-0817. DOI: 10.3390/pathogens9090688


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