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Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes

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Salmonella enterica serovar Abortusovis (S. Abortusovis) infection is one of the most important causes of infectious late-term abortion as well as birth of weak lambs in sheep in many countries throughout the world. Implementation of protocols based on the application of effective vaccines is one of the most effective approaches for controlling this disease, but variable efficacy has been reported, possibly related to factors associated with the host, the vaccine, the parameters used for determining efficacy and the challenge protocols. In this context, a new commercial inactivated vaccine (INMEVA; Laboratorios Hipra S.A., Spain) was evaluated in 20 control and 17 vaccinated gestating ewes, subcutaneously challenged at 90 days of gestation with 5 × 106 colony-forming units (cfu) of a wild strain of S. Abortusovis. Incidence of reproductive failures, bacterial vaginal excretion (by real time PCR), and lamb survival were evaluated as indicators of the vaccine`s level of protection. Moreover, humoral response (by ELISA test in serum samples) was studied. Vaccination was showed to be safe under the study conditions. Vaccine efficacy was demonstrated in two different ways: i) it significantly decreased the percentage of abortions [29.4% (5/17) in the vaccinated group compared to the control group (65%; 13/20)] and ii) there was a significant reduction of the overall vaginal excretion in the sampling period (3.05 log cfu/mL ± 0.84 in the vaccinated group vs. 5.68 ± 0.67 in the control group).
Given these results, the vaccine evaluated can be considered as an effective alternative for controlling S. Abortusovis infection in ovine flocks




Garcia-Seco T., Montbrau C., Fontseca M., March R., Sitja M., Dominguez L. y Bezos J..




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Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes

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Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes


Participantes:

Universidad ComplutenseServicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Hipra Scientific, S.L.U..

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Research in Veterinary Science
FACTOR YEAR Q
1.892 2019

NLMID: 401300

PMID: 33268004

ISSN: 0034-5288



TÍTULO: Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes


REVISTA: Res. Vet. Sci.


EDITORIAL: Elsevier


AUTORES: Garcia-Seco T., Montbrau C., Fontseca M., March R., Sitja M., Dominguez L. and Bezos J..


PARTICIPANTES VISAVET


First
Teresa García-Seco Romero
6th
Lucas Domínguez Rodríguez
Last
Javier Bezos Garrido

DOI: https://doi.org/10.1016/j.rvsc.2020.11.017


CITA ESTA PUBLICACIÓN:

Garcia-Seco T., Montbrau C., Fontseca M., March R., Sitja M., Dominguez L. y Bezos J. Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes. Research in Veterinary Science. In Press. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2020.11.017


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