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Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry


1 de agosto de 2018

Artículo de investigación publicado en Research in Veterinary Science


Campylobacter jejuni is the leading cause of food-borne bacterial enteritis in humans, with contaminated poultry products considered the main source of infection. To survive the food chain, C. jejuni utilizes multiple defense mechanisms that counter oxidative and aerobic stresses. In this study, we phenotypically characterised 63 C. jejuni strains with oxidative stress survival and antimicrobial susceptibility testing to investigate correlations between these two phenotypes against the source of the strains and the presence of the MarR regulators RrpA and RrpB which have a role in regulating the response to oxidative and aerobic stress. C. jejuni strains isolated from meat and neck skin displayed the highest resistance to oxidative stress. In addition, C. jejuni strains that have an rrpA+rrpB− profile exhibit increased resistance to oxidative stress and to antimicrobials. Here we establish a preliminary link between the distribution of RrpA and RrpB and the increased resistance to antimicrobials. This study provides insight into how the genotypic make up of C. jejuni can influence the ability of the bacterium to survive within areas of high oxygen stress, such as the food chain, and subsequently can have a potential negative impact on human health




Ugarte-Ruiz M., Dominguez L., Corcionivoschi N., Brendan WW., Dorrell N. y Gundogdu O.




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Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry

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Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry

Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Agri-Food and Biosciences Institute (AFBI).

University College LondonDepartment of Infectious Diseases. London School of Hygiene and Tropical Medicine (LSHTM). University College London (UCL).







Research in Veterinary Science
FACTOR YEAR Q
1.616 2017

NLMID: 401300

PMID: 29957495

ISSN: 0034-5288



TÍTULO: Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry


REVISTA: Res. Vet. Sci.


NUMERACIÓN: 119(2018)170-175


AÑO: 2018


EDITORIAL: Elsevier


AUTORES: Ugarte-Ruiz M., Dominguez L., Corcionivoschi N., Brendan WW., Dorrell N. and Gundogdu O.


PARTICIPANTES VISAVET


First
María Ugarte Ruiz
2nd
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1016/j.rvsc.2018.06.016


CITA ESTA PUBLICACIÓN:

Ugarte-Ruiz M., Dominguez L., Corcionivoschi N., Brendan WW., Dorrell N. y Gundogdu O. Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry. Research in Veterinary Science. 119(2018)170-175. 2018. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2018.06.016


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