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Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions

Artículo de investigación publicado en The Veterinary Record

In Press

BACKGROUND:
There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the benefit of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to Mycobacterium caprae.
METHODS:
Two groups of goats, a vitamin D-supplemented group and a non-supplemented control group, were housed for 10 months in direct contact with M caprae-infected adult goats. Upon contact with the infected adult goats, all animals were TB-tested every two months.
RESULTS:
No experimental evidence of a protective effect of vitamin D supplementation based on M caprae culture prevalence, TBL prevalence, median TBL score or the proportion of single versus multiple organs presenting TBL was observed.
CONCLUSION:
The results indicate that, in the conditions used in this study, vitamin D supplementation in goats does not reduce TB infection risk nor the diffusion and severity of TBL. In addition, vitamin D-supplemented goats presented hyperphosphataemia and renal injury with calcifications suggestive of vitamin D intoxication




Risalde MA., Roy A., Bezos J., Pineda C., Casal C., Diez-Guerrier A., Lopez-Villalba I., Fernandez-Manzano A., Moreno I., de Juan L., Dominguez L. y Gortazar C.




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Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions

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Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions


Participantes:

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Instituto Maimonides de Investigación Biomédica de CordobaInstituto Maimonides de Investigación Biomédica de Cordoba.

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de CórdobaDepartamento de Medicina y Cirugia Animal. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Laboratorios SYVA, S.A.Laboratorios SYVA, S.A..

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Instituto de Salud Carlos IIIServicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Universidad ComplutenseServicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

CZ VaccinesCZ Vaccines.







The Veterinary Record
FACTOR YEAR Q
2.101 2018

NLMID: 31164

PMID: 31690642

ISSN: 0042-4900



TÍTULO: Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions


REVISTA: Vet. Rec.


EDITORIAL: British Veterinary Medicine


AUTORES: Risalde MA., Roy A., Bezos J., Pineda C., Casal C., Diez-Guerrier A., Lopez-Villalba I., Fernandez-Manzano A., Moreno I., de Juan L., Dominguez L. and Gortazar C.


PARTICIPANTES VISAVET


3rd
Javier Bezos Garrido
6th
Alberto Antoine Díez Guerrier
8th
Álvaro Fernández Manzano
10th
Lucía de Juan Ferré
11th
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1136/vr.105411


CITA ESTA PUBLICACIÓN:

Risalde MA., Roy A., Bezos J., Pineda C., Casal C., Diez-Guerrier A., Lopez-Villalba I., Fernandez-Manzano A., Moreno I., de Juan L., Dominguez L. y Gortazar C. Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions. The Veterinary Record. In Press. (A). ISSN: 0042-4900. DOI: 10.1136/vr.105411


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