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Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs

Artículo de investigación publicado en Veterinary Research

18 de abril de 2022

Trained immunity is the capacity of innate immune cells to produce an improved response against a secondary infection after a previous unrelated infection. Salmonellosis represents a public health issue and affects the pig farming industry. In general, vaccination against salmonellosis is still facing problems regarding the control of distinct serovars. Therefore, we hypothesized that an immunostimulant based on heat inactivated Mycobacterium bovis (HIMB) could have an immune training effect in pigs challenged with Salmonella enterica serovar Choleraesuis (S. Choleraesuis) and decided to explore the amplitude of this non-specific immune response. For this purpose, twenty-four 10 days-old female piglets were randomly separated in three groups: immunized group (n = 10) received orally two doses of HIMB prior to the intratracheal S. Choleraesuis-challenge, positive control group (n = 9) that was only challenged with S. Choleraesuis, and negative control group (n = 5) that was neither immunized nor infected. All individuals were necropsied 21 days post-challenge. HIMB improved weight gain and reduced respiratory symptoms and pulmonary lesions caused by S. Choleraesuis in pigs. Pigs immunized with HIMB showed higher cytokine production, especially of serum TNFα and lung CCL28, an important mediator of mucosal trained immunity. Moreover, immunized pigs showed lower levels of the biomarker of lipid oxidation malondialdehyde and higher activity of the antioxidant enzyme superoxide dismutase than untreated challenged pigs. However, the excretion and tissue colonization of S. Choleraesuis remained unaffected. This proof-of-concept study suggests beneficial clinical, pathological, and heterologous immunological effects against bacterial pathogens within the concept of trained immunity, opening avenues for further research




Vaz-Rodrigues R., Ferreras-Colino E., Ugarte-Ruiz M., Pesciarioli M., Thomas J., Garcia-Seco T., Sevilla IA., Perez-Sancho M., Mateo R., Dominguez L., Gortazar C. y Risalde MA.




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Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs

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Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs



Participantes:

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER).

Indian Council of Agricultural ResearchIndian Council of Agricultural Research (ICAR).

Animal Husbandry Department.

Gobierno VascoInstituto Vasco de Investigación y Desarrollo Agrario (NEIKER). Gobierno Vasco.

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Instituto Maimonides de Investigación Biomédica de CordobaUnidad de Enfermedades Infecciosas. Hospital Universitario Reina Sofía de Córdoba. Instituto Maimonides de Investigación Biomédica de Cordoba.

Instituto de Salud Carlos IIIInstituto de Salud Carlos III (ISCIII).



Noticias relacionadas en otros medios:


- Nuevo avance español en la lucha contra la salmonelosis porcina - diarioveterinario.com

- Bacilos de tuberculosis inactivados frente a la salmonelosis en cerdos - animalshealth.es







Veterinary Research
FACTOR YEAR Q
3.683 2020

NLMID: 9309551

PMID: 35436975

ISSN: 0928-4249



TÍTULO: Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs


REVISTA: Vet. Res.


NUMERACIÓN: 53(1):31


AÑO: 2022


EDITORIAL: BMC


AUTORES: Vaz-Rodrigues R., Ferreras-Colino E., Ugarte-Ruiz M., Pesciarioli M., Thomas J., Garcia-Seco T., Sevilla IA., Perez-Sancho M., Mateo R., Dominguez L., Gortazar C. and Risalde MA.


PARTICIPANTES VISAVET


3rd
María Ugarte Ruiz
6th
Teresa García-Seco Romero
8th
Marta Pérez Sancho
10th
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1186/s13567-022-01047-8


CITA ESTA PUBLICACIÓN:

Vaz-Rodrigues R., Ferreras-Colino E., Ugarte-Ruiz M., Pesciarioli M., Thomas J., Garcia-Seco T., Sevilla IA., Perez-Sancho M., Mateo R., Dominguez L., Gortazar C. y Risalde MA. Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs. Veterinary Research. 53(1):31. 2022. (A). ISSN: 0928-4249. DOI: 10.1186/s13567-022-01047-8


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