Investigation published in Comparative Immunology, Microbiology and Infectious Diseases

October 1^st, 2018

Caprine TB causes chronic disease with severe economic and health consequences. We assessed the effect of intramuscularly administered heat-inactivated Mycobacterium bovis (M. bovis) on 20 kid goats (10 vaccinated, 10 controls), naturally exposed to M. caprae through close contact with infected goats. At necropsy, visible TB-compatible lesions were recorded in all animals with the exception of 1 control and 2 vaccinated goats. The median of the total lesion score was 9 (IQR 3-13.5) and 5 (IQR 3-6.75) in control and vaccinated goats, respectively (median lesion reduction 44.4%, p =  0.224). The lung lesions of the vaccinated goats were restricted to the caudal lobes, while 6 controls had additional lung lobes affected (p =  0.01). The median lung lesion score reduction in vaccinated goats was 100%; however, this reduction was not significant (p =  0.124), possibly due to the low sample size. Regarding the abdomen, only one vaccinated goat presented visible lesions compared to three goats in the control group. The results provide further evidence of the potential of heat-inactivated M. bovis for controlling TB in different host species, including ruminants

Roy A., Risalde MA., Bezos J., Casal C., Romero B., Sevilla I., Diez-Guerrier A., Rodriguez-Bertos A., Dominguez M., Garrido J., Gortazar C. and Dominguez L..

Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge

Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge

	CZ Veterinaria, S.A. (CZV).
	Servicio de Micobacterias (MYC). Servicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Laboratorios SYVA, S.A..
	Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER). Gobierno Vasco.
	MAEVA SERVET, S.L..
	Departamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Servicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).
	Sanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).