European 2-a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula
Infection Genetics and Evolution publica este artículo de investigación
1 de junio de 2012
Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.
Rodriguez-Campos S., Schürch AC., Dale J., Lohan AJ., Cunha MV., Botelho A., De Cruz K., Boschiroli ML., Boniotti B., Pacciarini M., Garcia-Pelayo MC., Romero B., de Juan L., Dominguez L., Gordon SV., van Soolingen D., Loftus B., Berg S., Hewinson RG., Aranaz A. y Smith NH.
 | Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | Centre for Infectious Disease Control. National Institute for Public Health and the Environment (RIVM). |
| Centre for Molecular and Biomolecular Informatics. Radboud University Nijmegen Medical Cente (UMCN). | |
 | Animal Health and Veterinary Laboratories Agency (AHVLA). |
 | UCD School of Medicine & Medical Science. University College Dublin (UCD). |
| Laboratório Nacional de Investigação Veterinária (LNIV). Instituto Nacional de Recursos Biologicos (INRB). | |
 | Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travail (ANSES). |
| Centro Nazionale di Referenza per la Tubercolosi Bovina. Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER). | |
| UCD Conway Institute of Biomolecular & Biomedical Research. University College Dublin (UCD). |
| Radboud University Nijmegen Medical Cente (UMCN). | |
 | Centre for the Study of Evolution (CSE). University of Sussex (US). |
