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Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease

Investigación publicada en Environmental Microbiology

1 de diciembre de 2019

The use of antimicrobials in human and veterinary medicine has coincided with a rise in antimicrobial resistance (AMR) in the food‐borne pathogens Campylobacter jejuni and Campylobacter coli. Faecal contamination from the main reservoir hosts (livestock, especially poultry) is the principal route of human infection but little is known about the spread of AMR among source and sink populations. In particular, questions remain about how Campylobacter resistomes interact between species and hosts, and the potential role of sewage as a conduit for the spread of AMR. Here we investigate the genomic variation associated with AMR in 168 C. jejuni and 92 C. coli strains isolated from humans, livestock and urban effluents in Spain. Antimicrobial resistance was tested in vitro and isolate genomes were sequenced and screened for putative AMR genes and alleles. Genes associated with resistance to multiple drug classes were observed in both species and were commonly present in multidrug‐resistant genomic islands, often located on plasmids or mobile elements. In many cases, these loci had alleles that were shared among C. jejuni and C. coli consistent with horizontal transfer. Our results suggest that specific antibiotic resistance genes have spread among Campylobacter isolated from humans, animals and the environment




Mourkas E., Florez-Cuadrado D., Pascoe B., Calland JK., Bayliss SC., Mageiros L., Meric G., Hitchings MD., Quesada A., Porrero MC., Ugarte-Ruiz M., Gutierrez-Fernandez J., Dominguez L. y Sheppard SK.




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Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease

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Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease


Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of OxfordDepartment of Zoology. University of Oxford.

Universidad de ExtremaduraDepartamento de Bioquímica, Biología Molecular y Genética. Facultad de Veterinaria. Universidad de Extremadura (UNEX).

Universidad de GranadaDepartamento de Microbiología. Facultad de Ciencias. Universidad de Granada (UGR).

Swansea UniversityCollege of Medicine. Swansea University.

Baker Heart and Diabetes InstituteCambridge Baker Systems Genomics Initiative. Baker Heart and Diabetes Institute.

University of BathMRC CLIMB Consortium (MRC CLIMB). University of Bath.

University of BathThe Milner Centre for Evolution. Department of Biology and Biochemistry. University of Bath.

Monash UniversityDepartment of Infectious Diseases. Central Clinical School. Monash University.







Environmental Microbiology
FACTOR YEAR Q
5.147 2018

NLMID: 100883692

PMID: 31385413

ISSN: 1462-2912



TÍTULO: Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease


REVISTA: Environ. Microbiol.


NUMERACIÓN: 21(12):4597-4613


AÑO: 2019


EDITORIAL: Wiley


AUTORES: Mourkas E., Florez-Cuadrado D., Pascoe B., Calland JK., Bayliss SC., Mageiros L., Meric G., Hitchings MD., Quesada A., Porrero MC., Ugarte-Ruiz M., Gutierrez-Fernandez J., Dominguez L. and Sheppard SK.


PARTICIPANTES VISAVET


11th
María Ugarte Ruiz
13th
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1111/1462-2920.14760


CITA ESTA PUBLICACIÓN:

Mourkas E., Florez-Cuadrado D., Pascoe B., Calland JK., Bayliss SC., Mageiros L., Meric G., Hitchings MD., Quesada A., Porrero MC., Ugarte-Ruiz M., Gutierrez-Fernandez J., Dominguez L. y Sheppard SK. Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease. Environmental Microbiology. 21(12):4597-4613. 2019. (A). ISSN: 1462-2912. DOI: 10.1111/1462-2920.14760


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