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Identification of Type VI secretion system (T6SS) in Spanish Campylobacter jejuni

Poster presentado en 17th International Workshop on Campylobacter, Helicobacter and Related Organisms

15 de septiembre de 2013

Ugarte-Ruiz M., Gundogdu O., Wassenaar T., Ancochea C., Porrero MC., Dorrell N., Wren B. y Dominguez L.

Campylobacteriosis is considered a public health concern in the European Union as the reported incidence continues to increase. Recently, a Type VI secretion system (T6SS) was identified in some C. jejuni strains that conferred enhanced virulence in cell-based assays and in mice. The gene hcp (hemolysin co-regulated protein) was identified as a conserved genetic marker to identify this T6SS. In parallel, C. jejuni possesses a variety of genes encoding important oxidative stress response proteins such as superoxide dismutase (SodB), catalase (KatA), or regulators like peroxide stress (PerR) and the newly identified Cj1556. These genes appear to play a role in C. jejuni persistence in the environment. In this study, strains from Spanish poultry at slaughterhouse (n=58) and water samples (urban effluent, n=4) were investigated. We performed PCR screening for presence of T6SS and notable genes involved in the production of proteins that play a role in oxidative stress. These, along with the oxidative stress assays, were assessed in order to characterize the C. jejuni collection. We found that the majority of strains (79%) possess the T6SS hcp gene and display a high level of resistance to oxidative stress irrespective of the isolates’ origin. The high incidence of T6SS may be significant C. jejuni -associated disease in the EU




Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).


Molecular Microbiology and Genomics Consultants.


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Identification of Type VI secretion system (T6SS) in Spanish Campylobacter jejuni


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Enlace a 17th International Workshop on Campylobacter, Helicobacter and Related Organisms





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17th International Workshop on Campylobacter, Helicobacter and Related Organisms


15-19 septiembre de 2013
Aberdeen
Reino Unido

TÍTULO: Identification of Type VI secretion system (T6SS) in Spanish Campylobacter jejuni


TIPO: Comunicación en póster


AUTORES: Ugarte-Ruiz M., Gundogdu O., Wassenaar T., Ancochea C., Porrero MC., Dorrell N., Wren B. y Dominguez L.


PARTICIPANTES VISAVET


First
María Ugarte Ruiz
4th
Carlos Ancochea Nodal
Last
Lucas Domínguez Rodríguez

FECHA: 15 de septiembre de 2013



CITA ESTA COMUNICACIÓN:

Ugarte-Ruiz M., Gundogdu O., Wassenaar T., Ancochea C., Porrero MC., Dorrell N., Wren B. y Dominguez L. Identification of Type VI secretion system (T6SS) in Spanish Campylobacter jejuni. 17th International Workshop on Campylobacter, Helicobacter and Related Organisms, University of Aberdeen, Aberdeen, Reino Unido, 15 de septiembre de 2013. (Comunicación en póster)


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