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Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19

Frontiers in veterinary science publica este artículo de investigación

15 de agosto de 2024

Introduction: As the SARS-CoV-2 virus continues to evolve and new variants emerge, it becomes crucial to understand the comparative pathological and immunological responses elicited by different strains. This study focuses on the original Wuhan strain and the Omicron variant, which have demonstrated significant differences in clinical outcomes and immune responses.
Methods: We employed ferrets as an experimental model to assess the D614G variant (a derivative of the Wuhan strain) and the Omicron BA.5 variant. Each variant was inoculated into separate groups of ferrets to compare disease severity, viral dissemination, and immune responses.
Results: The D614G variant induced more severe disease and greater viral spread than the Omicron variant. Notably, ferrets infected with the D614G variant exhibited a robust neutralizing antibody response, whereas those infected with the Omicron variant failed to produce a detectable neutralizing antibody response. Despite the clearance of the virus from nearly all tissues by 7 days post-infection, an increase in pathological lesions was observed from 14 to 21 days, particularly in those infected with the D614G variant, suggesting a sustained immune response even after viral clearance

Discussion: These findings underscore the adaptability of SARS-CoV-2 and illuminate how susceptibility and clinical manifestations vary across different strains and species. The results emphasize the necessity of considering both the direct effects of viral infection and the indirect, often prolonged, impacts of the immune response in evaluating the outcomes of SARS-CoV-2 infections.




Barroso-Arevalo S., Sánchez-Morales L., Porras N., Diaz-de Frutos M., Barasona JA., Isla J., López-Gutiérrez D., Gortazar C., Dominguez L. y Sanchez-Vizcaino JM..




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Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19

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Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19



Participantes:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Servicio de Patología y Veterinaria Forense (SAP). Servicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

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Frontiers in veterinary science
FACTOR YEAR Q
2.600 2023

NLMID: 101666658

PMID: 39211479

ISSN: 2297-1769



TÍTULO: Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19


REVISTA: Front Vet Sci


NUMERACIÓN: 11


AÑO: 2024


EDITORIAL: Lausanne : Frontiers Media S.A


AUTORES: Barroso-Arevalo S., Sánchez-Morales L., Porras N., Diaz-de Frutos M., Barasona JA., Isla J., López-Gutiérrez D., Gortazar C., Dominguez L. and Sanchez-Vizcaino JM..


First
Sandra Barroso Arévalo
2nd
Lidia Sánchez Morales
3rd
Néstor Porras González
5th
José Ángel Barasona García-Arévalo
7th
Débora López Gutiérrez
8th
Christian Gortazar Schmidt
9th
Lucas Domínguez Rodríguez
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3389/fvets.2024.1435464


CITA ESTA PUBLICACIÓN:

Barroso-Arevalo S., Sánchez-Morales L., Porras N., Diaz-de Frutos M., Barasona JA., Isla J., López-Gutiérrez D., Gortazar C., Dominguez L. y Sanchez-Vizcaino JM. Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19. Frontiers in veterinary science. 11. 2024. (A). ISSN: 2297-1769. DOI: 10.3389/fvets.2024.1435464


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