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Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures

Veterinary Immunology and Immunopathology publica este artículo de investigación

15 de octubre de 2015

Tuberculosis (TB) in goats (Capra hircus) is due to infection with members of the Mycobacterium tuberculosis complex (MTC), mainly Mycobacterium bovis and M. caprae. We report a comparative experimental infection of goats with M. bovis, M. caprae and M. tuberculosis strains. We hypothesized that goats experimentally infected with different members of the MTC would display different clinical pictures. Three groups of goats were challenged with either M. bovis SB0134 (group 1, n = 5), M. caprae SB0157 (group 2, n = 5) and M. tuberculosis SIT58 (group 3, n = 4). The highest mean total lesion score was observed in M. bovis challenged goats (mean 15.2, range 9-19), followed by those challenged with M. caprae (10.8, 2-23). The lowest score was recorded in goats challenged with M. tuberculosis (3, 1-6). Culture results coincided with the lesion scores in yielding more positive pools (7/15) in M. bovis challenged goats. By contrast, only three pools were positive from goats challenged M. tuberculosis (3/12) and with M. caprae (3/15), respectively. Differences in the performance of the intradermal and gamma-interferon (IFN-γ) tests depending of the group were observed since all goats from group 1 were diagnosed using intradermal test and these goats reacted earlier to the IFN-γ assay in comparison to the other groups. This study confirmed that goats experimentally infected with different members of the MTC display different clinical pictures and this fact may have implications for MTC maintenance and bacterial shedding




Bezos J., Casal C., Diez-Delgado I., Romero B., Liandris E., Alvarez J., Sevilla I., de Juan L., Dominguez L. y Gortazar C.




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Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures

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Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures


Participantes:

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Gobierno VascoNeiker-Tecnalia, Instituto Vasco de Investigación y Desarrollo Agrario. Gobierno Vasco.

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).







Veterinary Immunology and Immunopathology
FACTOR YEAR Q
1.664 2015

NLMID: 8002006

PMID: 26235598

ISSN: 0165-2427



TÍTULO: Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures


REVISTA: Vet. Immunol. Immunopathol.


NUMERACIÓN: 167(3-4):185-9


AÑO: 2015


EDITORIAL: Elsevier Scientific


AUTORES: Bezos J., Casal C., Diez-Delgado I., Romero B., Liandris E., Alvarez J., Sevilla I., de Juan L., Dominguez L. and Gortazar C.


PARTICIPANTES VISAVET


First
Javier Bezos Garrido
4th
Beatriz Romero Martínez
6th
Julio Álvarez Sánchez
8th
Lucía de Juan Ferré
9th
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1016/j.vetimm.2015.07.009


CITA ESTA PUBLICACIÓN:

Bezos J., Casal C., Diez-Delgado I., Romero B., Liandris E., Alvarez J., Sevilla I., de Juan L., Dominguez L. y Gortazar C. Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures. Veterinary Immunology and Immunopathology. 167(3-4):185-9. 2015. (A). ISSN: 0165-2427. DOI: 10.1016/j.vetimm.2015.07.009


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