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Molecular epidemiology of multidrug-resistant Mycobacterium bovis isolates with the same spoligotyping profile as isolates from animals

Artículo de investigación publicado en Journal of Clinical Microbiology

1 de septiembre de 2006

PCR-based characterization techniques have been adopted in most laboratories for Mycobacterium bovis typing. We report a molecular characterization of human multidrug-resistant M. bovis isolates and three bovine isolates that share the spoligotyping profile. The analysis of the direct repeat region showed that both groups differed in the presence of spacers not included in the current membrane. They were also distinguished by two out of the nine mycobacterial interspersed repetitive unit variable-number tandem repeat loci tested, indicating that the human infection was not acquired from the cattle from which isolates were obtained. These results highlight that a combination of techniques is required for appropriate discrimination, even for those spoligotypes that have a low frequency




Romero B., Aranaz A., de Juan L., Alvarez J., Bezos J., Mateos A., Gomez-Mampaso E. y Dominguez L..




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Molecular epidemiology of multidrug-resistant Mycobacterium bovis isolates with the same spoligotyping profile as isolates from animals

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Molecular epidemiology of multidrug-resistant Mycobacterium bovis isolates with the same spoligotyping profile as isolates from animals


Participantes:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Hospital Universitario Ramón y Cajal. Instituto Madrileño de la Salud (IMSALUD). Comunidad de Madrid.

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Journal of Clinical Microbiology
FACTOR YEAR Q
3.445 2006

NLMID: 7505564

PMID: 16954286

ISSN: 0095-1137



TÍTULO: Molecular epidemiology of multidrug-resistant Mycobacterium bovis isolates with the same spoligotyping profile as isolates from animals


REVISTA: J. Clin. Microbiol.


NUMERACIÓN: 44(9):3405-8


AÑO: 2006


EDITORIAL: American Society for Microbiology


AUTORES: Romero B., Aranaz A., de Juan L., Alvarez J., Bezos J., Mateos A., Gomez-Mampaso E. and Dominguez L..


PARTICIPANTES VISAVET


First
Beatriz Romero Martínez
3rd
Lucía de Juan Ferré
4th
Julio Álvarez Sánchez
5th
Javier Bezos Garrido
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1128/JCM.00730-06


CITA ESTA PUBLICACIÓN:

Romero B., Aranaz A., de Juan L., Alvarez J., Bezos J., Mateos A., Gomez-Mampaso E. y Dominguez L. Molecular epidemiology of multidrug-resistant Mycobacterium bovis isolates with the same spoligotyping profile as isolates from animals. Journal of Clinical Microbiology. 44(9):3405-8. 2006. (A). ISSN: 0095-1137. DOI: 10.1128/JCM.00730-06


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