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Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats

Artículo de investigación publicado en The Veterinary Journal

1 de mayo de 2017

The development of new vaccines against animal tuberculosis (TB) is a priority for improving the control and eradication of this disease, particularly in those species not subjected to compulsory eradication programmes. In this study, the protection conferred by the Mycobacterium tuberculosis SO2 experimental vaccine was evaluated using a natural infection model in goats. Twenty-six goats were distributed in three groups: (1) 10 goats served as a control group; (2) six goats were subcutaneously vaccinated with BCG; and (3) 10 goats were subcutaneously vaccinated with SO2. Four months after vaccination, all groups were merged with goats infected with Mycobacterium bovis or Mycobacterium caprae, and tested over a 40 week period using a tuberculin intradermal test and an interferon-γ assay for mycobacterial reactivity. The severity of lesions was determined at post-mortem examination and the bacterial load in tissues were evaluated by culture. The two vaccinated groups had significantly lower lesion and bacterial culture scores than the control group (P < 0.05); at the end of the study, the SO2 vaccinated goats had the lowest lesion and culture scores. These results suggest that the SO2 vaccine provides some protection against TB infection acquired from natural exposure




Bezos J., Casal C., Alvarez J., Roy A., Romero B., Rodriguez-Bertos A., Barcena C., Diez-Guerrier A., Juste R., Gortazar C., Puentes E., Aguilo N., Martin C., de Juan L. y Dominguez L..




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Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats

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Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats


Participantes:

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Gobierno del Principado de AsturiasServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA). Gobierno del Principado de Asturias.

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

BIOFABRI, S.L.BIOFABRI, S.L..

Universidad de ZaragozaDepartamento de Microbiología, Medicina Preventiva y Salud Pública. Facultad de Medicina. Universidad de Zaragoza (UNIZAR).

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).

Universidad ComplutenseServicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







The Veterinary Journal
FACTOR YEAR Q
1.773 2017

NLMID: 9706281

PMID: 28671074

ISSN: 1090-0233



TÍTULO: Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats


REVISTA: Vet. J.


NUMERACIÓN: 223(2017):60-67


AÑO: 2017


EDITORIAL: Elsevier SCI LTD


AUTORES: Bezos J., Casal C., Alvarez J., Roy A., Romero B., Rodriguez-Bertos A., Barcena C., Diez-Guerrier A., Juste R., Gortazar C., Puentes E., Aguilo N., Martin C., de Juan L. and Dominguez L..


PARTICIPANTES VISAVET


First
Javier Bezos Garrido
3rd
Julio Álvarez Sánchez
5th
Beatriz Romero Martínez
6th
Antonio Manuel Rodríguez Bertos
7th
Carmen Bárcena Asensio
8th
Alberto Antoine Díez Guerrier
14th
Lucía de Juan Ferré
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1016/j.tvjl.2017.04.006


CITA ESTA PUBLICACIÓN:

Bezos J., Casal C., Alvarez J., Roy A., Romero B., Rodriguez-Bertos A., Barcena C., Diez-Guerrier A., Juste R., Gortazar C., Puentes E., Aguilo N., Martin C., de Juan L. y Dominguez L. Evaluation of the Mycobacterium tuberculosis SO2 vaccine using a natural tuberculosis infection model in goats. The Veterinary Journal. 223(2017):60-67. 2017. (A). ISSN: 1090-0233. DOI: 10.1016/j.tvjl.2017.04.006


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