Research

Epidemiology of resistance to aminoglycosides and macrolides in thermotolerant Campylobacter in livestock in Spain

PhD Thesis defense by Vicente López Chavarrías at the VISAVET Centre of the Complutense University of Madrid

Antimicrobial resistance is a major problem for the treatment of diseases caused by zoonotic bacteria such as thermotolerant Campylobacter (C. coli and C. jejuni). The mechanisms by which antimicrobial resistance spreads over bacterial populations, especially via horizontal gene transfer, can have broad consequences depending on the speed at which resistant phenotypes disseminate through food animal hosts, humans and the environment. Particularly relevant are genetic determinants capable of conferring resistance to three or more antimicrobial classes, making treatments more complicated when mu… Leer más

Estudio histopatológico e inmunohistoquímico de la expresión de integrinas en el carcinoma gástrico canino

Degree Final Project defended by Adrian Arribas Mercado

Gastric carcinoma represents 60–70% of gastric neoplasms in dogs. The malignancy of these neoplasms is based on cellular characteristics such as pleomorphism, anisocytosis, anisokaryosis, atypical mitoses and mitotic index among others; but undoubtedly, migration, infiltration and metastasis of neoplastic cells are the criteria that determine the invasiveness of a tumor. These criteria can be determined by immunohistochemical study of certain transmembrane proteins called integrins. These molecules are composed of two separate subunits, ? (alpha) and ? (beta) subunits, which combine to form … Leer más

Veterinaria forense: estudio de la senescencia celular en perros emaciados procedentes de abuso animal

Alba Revilla Ruiz defended this Degree Final Project

Animal abuse is an increasing concern in society, and veterinary forensic pathologists play a critical role in combating maltreatment by identifying non-accidental injuries in animals. This study aimed to comparatively analyze the macro and microscopic lesions, as well as p53 immunoexpression, in dogs with varying degrees of emaciation (Body Condition 1, 2 and 3) from suspected cases of abuse. Anatomopathological findings were thoroughly examined, and immunohistochemical techniques were applied to key tissues to evaluate nuclear p53 expression as a marker of cellular damage and potential senes… Leer más

Determinación de la circulación del virus Toscana en lagomorfos de la Comunidad de Madrid

Degree Final Project defended by Sofía Gansievich Levit

El virus Toscana (TOSV) es un flebovirus perteneciente a la familia Phenuiviridae, transmitido por flebótomos, principalmente de los géneros P. perniciosus y P. perfilewi. Este virus presenta neurotropismo y puede causar meningitis y meningoencefalitis. Desde su descubrimiento en Italia en 1971, se ha documentado su presencia en diversos países del Mediterráneo, incluyendo España. A través de estudios serológicos y moleculares, se ha demostrado la circulación del virus en humanos y animales domésticos y silvestres, lo que indica una epidemiología compleja y posiblemente infradiagnost… Leer más

Evaluación de técnicas ante-mortem frente a tuberculosis en camélidos del nuevo mundo

Degree Final Project defended by Sofía Cobos Blázquez

Evaluación del rendimiento de técnicas complementarias para el diagnóstico de tuberculosis en ganado caprino

Sergio Lobo Campillo defended this Degree Final Project

Detection of Coxiella burnetti in wild rabbits in the Community of Madrid

Cindy López Sánchez defended this Degree Final Project

Q fever is an emerging zoonosis caused by the multi-host bacterium Coxiella burnetii, which has a worldwide distribution and affects numerous animal species. Spain is one of the countries that reports the most cases annually to the ECDC. Ruminants are the main source of infection for humans, although wildlife plays a significant role as a reservoir for this pathogen, particularly the European rabbit (Oryctolagus cuniculus), whose populations are increasing due to factors such as species traits, regional characteristics, and changes in interaction patterns between rabbits, domestic animals and … Leer más

On-farm dynamics of antibiotic resistance genes in Escherichia coli from hen gut microbiota during the commercial egg production cycle

PhD Thesis defense by Irene Aldea Ramos at the VISAVET Centre of the Complutense University of Madrid

Antibiotic resistance is a public health problem facing society, with fewer and fewer therapeutic options available for the treatment of infections caused by resistant bacteria. Production animals can transmit these resistant bacteria to humans through the food chain, so the use of antibiotics in these animals is restricted at both European and national level. In this thesis, the role of the gut microbiota of animals (from day-old chicks to 84-85 weeks old laying hens) in the spread of antimicrobial resistance of Escherichia coli was studied in a commercial layer farm, providing a closed s… Leer más

Characterization of shedding, transmission, and environmental contamination of different strains of African swine fever virus

PhD Thesis defense by Aleksandra Kosowska at the VISAVET Centre of the Complutense University of Madrid

The rapid and widespread outbreaks of African swine fever (ASF) across multiple continents have underscored the urgent need for effective control strategies to mitigate its devastating impact. ASF is a highly contagious hemorrhagic disease affecting domestic pigs and wild boar, with severe consequences for animal health, international trade, and regional economies. Caused by a large, complex double-stranded DNA virus, ASF virus (ASFV) can persist in the environment for extended periods, facilitating indirect transmission and long-term circulation. As a notifiable disease under the World Organi… Leer más

Epidemiology of non-typhoidal Salmonella in livestock production and characterization of emerging serovars of public health interes

PhD Thesis defense by Clara Samper Cativiela at the VISAVET Centre of the Complutense University of Madrid

Non-typhoidal Salmonella (NTS) serovars cause salmonellosis, a globally relevant foodborne zoonosis primarily characterized by gastrointestinal manifestations. Since the mid-20th century, surveillance and control measures have been implemented along the food chain to mitigate its health and economic impact. However, human incidence and prevalence of NTS infection in animal reservoirs remain high. This is due to the complexity of its epidemiology, involving multiple animal species that can act as asymptomatic carriers, and the increasing emergence of antimicrobial-resistant strains, a phenomeno… Leer más